RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
Neat1
RNA ID
RNA Type
lncrna
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
NA
Target
NA
Pathway
NA
PubMed ID
Title
NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6
Year
2017
Function
Neat1 was significantly increased in ccl4-induced mice and activated hscs. Loss of neat1 suppressed liver fibrosis in vivo and in vitro. Klf6 and mir-122 were required for the effects of neat1 on hsc activation. Neat1 contributes to hsc activation via competitively binding mir-122. We disclose a novel neat1-mir-122-klf6 signaling cascade.